A new couple get married and move to Switzerland. They make friends with their new neighbors Akshay Kumar and Bipasha Basu. Life seems perfect until one day when Raj wakes up in Vicky's house and finds out that Vicky's wife has been murdered. Raj is accused of the murder but flees from the authorities in order to prove himself innocent.

Slender, barely 5'2", assisting a dance troupe, Veera Kaur's dream is to represent the 9-time losing Indian Tigers cricket team. The team, led by Choudhary Vikramjeet Singh, have never won the Aman Cup against their rivals, Pakistan Champs, led by Pathan Liqayat Ali Khan. She dons the guise of a turbaned Sikh, complete with beard and mustache, and calls herself Veer Pratap Singh. In this way she manage to convince the new, rather arrogant and brash Team Captain, Rohan Singh, a British County Cricket all-rounder, and the son of Vikramjeet, to include her in this team. Things all appear to be going well until accusations are leveled against her for attempting to sexually molest Rohan's leggy girlfriend - none other than Miss Chandigarh 2008, Soniya Saluja - which may well blow her cover, and prevent her from ever playing for any Indian Cricket team.

The only male child in the family that sired six daughters, Prem has empathy towards the fair sex and decides to assist males to woo women so much so that he becomes popular as the 'Love Guru'. Amongst the men he assists are Bhaskar Chaudhry and Neil Bakshi. Klutz-like Bhaskar has fallen head over heels with his boss, a model and heiress, Priya Jaisingh. A disbelieving Prem refuses to assist him, but subsequently relents. Bhaskar uses his own charm to woo Priya successfully, and is introduced to her dad, Raj. Prem himself falls in love with a widowed single mother, Naina Shahani, a Journalist. Both men are satisfied with her respective lives not knowing that a scandalous secret will surface in the media - changing their lives forever.

Originally from India, Tamil-speaking Shekar Subramaniam lives a middle-classed life abroad along with his wife, Sonia, and a school-going son, Prateek. While Sonia is busy writing a book on converting all female-related expletives to male, her husband is employed with Barron Industries, where the owner insists his staff come up with a plan to launch the ultimate video game or else he will change his organization to a restaurant and hire them as waiters. Hoping to create a super-hero, Shekhar instead faces criticism from Prateek - who hopes to instead see a kick-ass villain. This conversation does change Shekhar's thinking and he sets about to create an indestructible villain, calls him Ra.one (pronounced as in Lankeshwar Ravan) and its arch-enemy G.One (Jeevan). Prateek will have to regret passing on this idea on to his father - for soon their lives will be shattered when the shape-shifting Ra.One will find a way to enter the real world...